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KMID : 0665220150280010111
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Korean Journal of Food and Nutrition
2015 Volume.28 No. 1 p.111 ~ p.118
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3,4-Dihydroxytoluene Inhibits Epidermal Growth Factor-induced Cell Transformation in JB6 P+ Mouse Epidermal Cells by Suppressing Raf-1
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Kim Ji-An
Kim Ji-Hye
Eric di Ruccio
Kang Nam-Joo
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Abstract
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In summary, the rutin metabolite DHT significantly reduced EGF-induced neoplastic transformation in JB6 P+ cells. This inhibition was mediated mainly by blocking the Raf/MEK/ERK signaling pathway and subsequent suppression of AP-1 activities. DHT attenuated Raf-1 kinase activity by directly binding to Raf-1 in vitro and ex vivo. Taken together, these results suggest that Raf-1 may be a critical molecular target to suppress DHT-induced neoplastic transformation, which is mainly attributable to the chemopreventive potential of several foods containing rutin.
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KEYWORD
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DHT , EGF , Raf-1
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